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bound forms, and the free testosterone concentration will determine its half-life. About 90 percent of a dose of testosterone is excreted in the urineas glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of testosterone occurs There is considerable variation in the half-life of testosterone as reported in the literature, ranging from 10 to 100 minutes. Testosterone is metabolized to various 17-keto steroids through two different pathways. The major active metabolites of testosterone are estradiol and DHT. Testosterone is metabolized to various 17-keto steroids through two different pathways. The half-life of testosterone cypionate when injected intramuscularly is approximately eight days. In many tissues the activity of testosterone appears to depend on reduction to dihydrotestosterone, which binds to cytosol receptor proteins. The half-life of Testosterone Propionate is approximately two days, which is substantially longer than ester free testosterone, which carries a half-life a little less than 24 hours. As a pure testosterone, Testosterone Propionate carries an anabolic rating of 100 and an androgenic rating of 100 as well.

half-life of testosterone The half-life of testosterone cypionate when injected intramuscularly is approximately eight days. In many tissues the activity of testosterone appears to depend on reduction to dihydrotestosterone, which binds to cytosol receptor proteins. The half life of each ester is one of the main differences between them. Cypionate has an approximately 8 day half life, Enanthate and Propionate have a short elimination half life of about 4.5 days. Testosterone Undecanoate has a long half life of over 20 days, and Phenylpropionate has a very short half life of less than three days. Testosterone Enanthate is the most popular ester variant of the testosterone steroid. It has a half life of about 8 to 10 days and is a slow release testosterone steroid used in injectable form either for performance enhancement or as a TRT. This indicates that the T gel preparations had a longer effective half-life than the T patch (Table 2 and Fig. 2). Figure 2. Preapplication serum T ( upper panel ), free T ( middle panel ), and percent free T ( lower panel ) concentrations during daily treatment with T gel or patch from days 1 90 ( left panel ) and days 90 180 ( right panel ).